Studies on the Effect of Enamel Matrix Derivatives on Early Wound Healing. Which Applications Are Evidence-based?
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چکیده
REZUMAT STUDIES ON THE EFFECT OF ENAMEL MATRIX DERIVATIVES ON EARLY WOUND HEALING. WHICH APPLICATIONS ARE EVIDENCE-BASED? Stefan-Ioan Stratul1, Darian Rusu1, Anton Sculean2 The goal of regenerative periodontal therapy is the reconstitution of the lost periodontal structures (i.e. the new formation of root cementum, periodontal ligament and alveolar bone). Results from basic research have pointed to the important role of the enamel matrix protein derivative (EMD) in the periodontal wound healing. Histological results from animal and human studies have shown that treatment with EMD promotes periodontal regeneration. Moreover, clinical studies have indicated that treatment with EMD positively influences periodontal wound healing in humans. The goal of the current overview is to present, based on the existing evidence, the clinical indications for regenerative therapy with EMD.
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